Silence Blog

Mini-review published highlighting new antisense technologies paper in Silence

In an article published in Silence today, Zheng et al describe how dextran was conjugated with 2'-O-methyl oligoribonucleotides to develop fluorescently labeled antisense reagents which were targeted to block specific miRNAs.  These antisense oligonucleotides were introduced into the germ line of adult hermaphrodite C. elegans, and passed onto the worms progeny, where they were successfully shown to have efficiently and specifically inhibited Lin-4 miRNA in several different tissues.

The article is further discussed in a mini-review by Slack et al, published in Journal of Biology.

The authors anticipate that this new class of antisense oligonucleotide will offer scientists a new experimental approach complimentary to the mutational strategy currently used for the study of miRNA function in vivo.

Posted by Emma Pettengale at 10:49    Comments (0)