International Archives of Medicine Blog

Late-onset AD is largely idiopathic, and has 2 distinct pathological features – extracellular amyloid plaques and intracellular neurofibrillary tangles. Encouragingly, recent studies have also indicated that both Ab42 and tau have significant predictive powers in cases of MCI progressing to AD. In particular, simultaneous measurement of CSF levels of Ab peptides and tau, and expressing these levels as various ratios, help to increase the sensitivity and specificity of prediction. There are also studies with findings that indicate the ability of these markers to tell AD apart from other forms of dementia. CSF Ab and tau could also be promising antecedent biomarkers that could predict the future development of dementia in cognitively normal older adults. But obtaining CSF requires a lumbar punction which migh be a traumatic procedure and a more accesible sample is highly desired.You can find a database with biomarkers of AD at Telemakus AD.

In this manuscript, Menendez-Gonzalez et al. reported that measuring plasmatic neurosin concentration is useful to predict conversion of patients diagnosed with MCI and we established the relative risks of developing AD and Dementia with vascular component according with the plasmatic level of neurosin. The prospect of seeing how plasma biomarkers correlate with the clinical findings is an exciting one and we need keep walking through this way.

Article in full text.