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BioMed Central Blog

Friday Nov 30, 2007

Journal of Trauma Management & Outcomes - a new open access journal from BioMed Central

We are pleased to announce the launch of Journal of Trauma Management & Outcomes, a new open access journal from BioMed Central. The journal considers articles on all aspects of trauma research, with a focus on interventions demonstrating efficacy and effectiveness in improving clinically relevant outcomes for severely injured patients such as mortality, morbidity, quality of life, function, and costs.

The journal is lead by the Editor-in-Chief, Professor Axel Ekkernkamp (Unfallkrankenhaus Berlin and University of Greifswald, Germany), who is supported by an expert Editorial Board

The first research articles published in Journal of Trauma Management & Outcomes focus of a variety of different areas including:

Please read the launch editorial for further information about the journal.


 

Thursday Nov 29, 2007

Trials publishes its first thematic series

Trials, BioMed Central's journal dedicated to exploring any aspect of the design, performance, and findings of randomized controlled trials in  health care, has recently published a series of articles on Standardization of outcomes, the latest of the journal's thematic series.

The series includes a review by Travis et al., which highlights the need for clear patient selection criteria and agreed definitions of disease remission in ulcerative colitis trials. This principle has successfully been applied in rheumatology, and is discussed in Tugwell et al.'s commentary, which also forms part of the series. Finally, Dr Mike Clarke provides an overview of the series in his commentary, and discusses the rationale for standardization initiatives in both clinical trials and systematic reviews. All of the articles are open access.

Commentary    
Standardising outcomes for clinical trials and systematic reviews
Mike Clarke

Commentary    
OMERACT: An international initiative to improve outcome measurement in rheumatology
Peter Tugwell, Maarten Boers, Peter Brooks, Lee Simon, Vibeke Strand, Leanne Idzerda

Review    
Outcome measurement in clinical trials for ulcerative colitis: towards standardisation
Rachel M Cooney, Bryan F Warren, Douglas G Altman, Maria T Abreu, Simon PL Travis

Trials is overseen by Doug Altman (United Kingdom), Curt Furberg (United States), Jeremy Grimshaw (Canada) and Peter Rothwell (United Kingdom), the Editors-in-Chief, and an expert editorial board. If you would like more information on the journal, please contact the editorial office.

Iain Hrynaszkiewicz
In-house Editor, Trials


 

Friday Nov 23, 2007

BioMed Central YouTube channel debuts

We're pleased to announce the launch of our new BioMed Central YouTube channel, which brings together videos of our authors and editors talking about their work, BioMed Central's journals, and the benefits of open access publishing.

 BioMed Central YouTube channel

Video is an increasingly important way for researchers to communicate their results, and BioMed Central is at the forefront of developments in this area. We encourage authors and editors to upload suitable videos to YouTube and contact us so that we can add these videos to the BioMed Central channel. If you want to know when we post new videos, just click the 'Subscribe' link on the channel home page.

In addition to our YouTube channel, we are working with SciVee to ensure the visibility and linking of PubCasts featuring BioMed Central articles. For example, SciVee currently features a pubcast by Apostol Gramada  in which he describes the research he published in BMC Bioinformatics.

BioMed Central also offers perhaps the best and most fully integrated support for video content within research articles of any scientific publisher. Thumbnails are displayed for any video files associated with an article, and these videos can be played back within the context of the article.

Examples of the diverse recent BioMed Central articles making use of this support for embedded video include:

We encourage and support authors who wish to publish video-enhanced articles, and to this end we have recently doubled the maximum file size for additional material files to 20 megabytes (using modern video standard such as MP4, this  is sufficient for several minutes of high quality video).


 

Thursday Nov 22, 2007

Biology Direct launches new Discovery Notes section

We are delighted to announce the launch of a new Discovery Notes section for Biology Direct, overseen by Section Editor L Aravind, and Editors-in-Chief David J Lipman, Laura Landweber, and Eugene Koonin.

Discovery Notes will be brief reports of specific discoveries made by computational analysis of nucleic acid and/or protein sequences, structures or other data, with novel observations and conclusions about the function, organization, or evolution of proteins, genes or genomes. These succinct articles will be an exciting addition to Biology Direct, as they will allow the rapid communication of key findings, and the novel connections and relationships which they identify will spur experimental investigations in new and unexpected directions.  Full details are available in an Editorial which launches the new section:

Opening Pandora's Box: making biological discoveries through computational data exploration
L Aravind
Biology Direct 2007, 2:29 (20 November 2007)

Biology Direct, which was launched in 2006, operates a unique open peer review system, whereby reviewers’ comments and authors’ responses are published alongside the final article, making the process of peer review open, rather than anonymous.  The journal has published more than 60 articles; nearly half of which have been accessed more than 2,000 times, and seven of which have been highlighted on the literature recommendation service Faculty of 1000 Biology. Biology Direct  is tracked by Thomson Scientific and is due to receive its first impact factor in 2008. As an open access publication, all articles are freely and immediately available online, maximising the visibility of the author's work, and copyright is retained by the author.


 

Monday Nov 19, 2007

Enthusiasm for open access on the Harvard campus

As has been blogged elsewhere, the student-organized event Publishing in the New Millennium: A Forum on Publishing in the Biosciences, which took place at Harvard University on November 9th, brought together a diverse panel of speakers to discuss the changing world of biomedical research publishing.  Thanks to a fortunate coincidence of scheduling, I was in Boston and able to attend - although only just - it was standing-room only in the auditorium, confirming the importance attached to this topic by students and faculty.

Much of the afternoon’s discussion revolved around open access and associated issues. The benefits of open access were clearly laid out in an opening keynote by Harold Varmus, Nobel Laureate and former Director of the NIH. A campus-level perspective on open access was then provided by Stuart Shieber, Professor of Computing at Harvard and Isaac Kohane, Director of Harvard Medical School’s Countway Library - both strong open access advocates.

Something which came across clearly at this forum, and in related discussions with administrators and faculty at Harvard and its neighbour MIT, is that open access is no longer simply a matter for discussion. The question has become how best to achieve it, and concrete steps are being taken.

 

As one example, Kohane mentioned that, in the light by the low rate of compliance by authors with NIH’s currently voluntary Public Access Policy, Harvard Medical School would be actively helping the process along by assisting faculty with the upload of  manuscript versions of their published articles to NIH’s open access archive, PubMed Central. On another front, as reported in the Harvard Crimson, Stuart Shieber has put forward a motion to the Faculty Council of Harvard’s Faculty of Arts and Sciences calling for a faculty-wide mandatory policy of open access. Over at MIT, similar moves are afoot.

 

More broadly, there is increasing recognition that moves towards open access will require a fundamental shift in how the communication of research findings is paid for. If full and immediate open access is to become the norm,  then publishers' subscription revenues will have to be replaced with other revenue streams. The cost of the research publication process may best  be seen as an integral part of the cost of carrying out, and then disseminating, the research, rather than being a 'content acquisition' cost payable by the library. At Harvard, there is talk of creating an Office of Research Communication that could help plan for and manage such a transition.

 

As previously noted on this blog, the UK Research Councils late last year issued a guidance note on the payment of publication fees, which paved the way for institutions such as Nottingham University to set up central open access funds, paid for using a share of indirect cost funding (payments received by universities from research funders to cover infrastructural expenditure etc).

 

Central funding of publication costs has an important role to play in facilitating the growth of open access publishing. If subscriptions are centrally supported (through library budgets), yet open access publication costs are not, authors may be put off by financial obstacles to open access publication, even when open access journals offer a demonstrably more efficient and better value service.  BioMed Central’s experience confirms that institutions which put in place a central payment schemes (such as BioMed Central membership) see an increased rate of growth in the uptake of open access publishing, as compared to when authors are expected to pay publication charges directly from their own grant funds.

 

To date, the National Institutes of Health, the largest funder of biological and medical research in the United States, has not yet issued any guidance regarding the applicability of indirect research funding for the central payment of research communication costs such as publication fees. Explicit confirmation from NIH, and other major US funders, that indirect costs can be used in this way could help to accelerate the growth of open access at Harvard, MIT and other US campuses, by facilitating  the creation of central open access funds. We see this as an important next step in the overall shift towards a sustainable and scaleable open access publishing model.

 


 

Journal of Biology publishes minireview on landscape genetics in the ocean, highlighting a study of porpoise populations published in BMC Biology

Journal of Biology, the premier biology journal published by BioMed Central, has published the first minireview covering an article from the BMC series of journals.

 

In the review, entitled Landscape genetics goes to sea, Michael Hanson and Jakob Hemmer-Hansen discuss the constraints placed on the gene flow of marine populations by environmental and geographical barriers.  This review highlights a recent study by Fontaine et al, published in BMC Biology, describing how such constraints may have led to the genetic isolation of populations of harbour propoises in some locations.

 

 

The scope of minireview articles in Journal of Biology was recently expanded to include open access articles of particular interest published by BioMed Central, and this is the first such article to appear in the journal. 


 

ENCODE E-GASP gene prediction workshop supplement now available in print via Amazon

We are pleased to announce that a collection of articles based on presentations made at the ENCODE E-GASP 2005 gene prediction workshop, originally published as an open access online supplement in Genome Biology, is now available to purchase as a print edition from Amazon.co.uk and Amazon.comAt E-GASP, a two day workshop held in Cambridge, UK, the results of a competition between 18 different labs to improve gene-prediction software for the human genome were discussed.  The results and their implications are reported in this supplement, which was edited by Roderic Guigó and Martin G Reese.

Genome Biology serves the biological research community as an international forum for the dissemination, discussion and critical review of information about all areas of biology informed by genomic research.  Another supplement containing a collection of articles on Transposons in vertebrate functional genomics, edited by Stephen C Ekker and Zoltán Ivics has also recently been published online by Genome Biology.


 

Saturday Nov 17, 2007

Highly accessed Nutrition Journal article on supplement usage demonstrates key benefit of open access

A recent article published in BioMed Central's open access Nutrition Journal concerning the usage patterns of dietary supplements and the health and nutritional status of their users has been downloaded from the journal's website over 16,000 times since publication on October 24th.

These remarkable access statistics demonstrate the extent to which open access journals can enhance the dissemination of
research, and emphasize the readiness of members of the public to dig behind the media coverage to read original research articles when they are accessible.

Ben Goldacre, on his excellent Bad Science blog, recently discussed the contrasting case of a research article, published in the Journal of the American Medical Association (JAMA) and widely covered in the popular media, which reported on the relative effectiveness of acupuncture, "sham acupuncture" and standard medical treatment in the treatment of lower back pain.

Lower back pain, like nutritional supplement usage, is an issue of relevance to a large fraction of the general population. Despite this, however, Goldacre's attempts to persuade JAMA to make the article freely available so that the public could read it for themselves were unsuccessful - particularly problematic considering that, as discussed by Goldacre, much of the media coverage failed to convey the key result of the research, which was that there was no statistically significant difference in the effectiveness of 'real' and 'sham' acupuncture.

Public access to relevant medical research is not the only benefit of open access publishing, but it is a significant one. For other examples of recent articles that have attracted a wide readership, see BioMed Central 'Most viewed' page.


 

Friday Nov 16, 2007

BMC Systems Biology gets off to a flying start - tracked by Thomson Scientific and 50 articles published

BMC Systems Biology is just 11 months old, but has already achieved some impressive milestones.

Not only has it just published its 50th article, but it has also recently been accepted for tracking by Thomson Scientific and is due to receive an official Impact Factor in June 2009. The journal is also now indexed by MEDLINE, BIOSIS Previews and Zoological Record.

The 'word cloud' below, based on article abstracts, gives a sense of the scope of the articles that the journal has published so far.

 Word cloud for BMC Systems Biology

Publications have looked at network modules and patterns, cellular signalling networks, modelling and designing genetic regulatory networks, cell cycle control and genetic oscillators, cell motility and cell proliferation kinetics, reconstructing metabolic pathways and networks, metabolic flux analysis, matching gene expression networks to phenotypes, spatial co-expression and connectivity in the brain, a gene search engine, and a model of the connective tissue network.

Whether you are working in one of these areas, or in another area of systems biology, you can submit your manuscript online.


 

Thursday Nov 08, 2007

Drosophilid genome studies published

Today sees the announcement in Nature by the Drosophila 12 Genomes Consortium of a further 10 drosophilid genome sequences, which were the talk of the 48th Annual Drosophila Research Conference earlier this year.

BioMed Central's journals are publishing seven open access companion papers analyzing these genome sequences. The papers in Genome Biology, BMC Genomics, BMC Evolutionary Biology and BMC Bioinformatics span a wide range of topics, including genome-wide surveys of RNAs, codon usage, comparative genomics of gene families and the evolution of gene order and sequences.

The sequencing of the Drosophila melanogaster genome at the turn of the millennium was a landmark in genome research, acting as a stepping stone to the human genome, and furthering understanding of this favourite model organism. The publication of the Drosophila pseudoobscura genome built upon this. As the Drosophila genus has over 2,000 known species, there is enormous scope in sequencing further members of this genus to study the molecular evolution of closely related genomes.

D. simulans and D. yakuba were sequenced by the Washington University Genome Center, D. erecta, D. ananassae, D. virilis, D. mojavensis and D. grimshawi were sequenced by Agencourt, Inc., D. willistoni was sequenced by the J. Craig Venter Institute, and D. persimilis and D. sechellia were sequenced by the Broad Institute.

Among the articles published by BioMed Central, a trio of papers studies global genomic patterns, looking at codon usage, sequence evolution and the evolution of gene order and chromosome rearrangements.

Two papers study the conservation of sequence motifs to uncover novel microRNAs and other non-coding RNAs.

On a smaller scale these sequences allow comparative studies of the evolution of gene families, and two papers analyze oxidative phosphorylation genes and the Odorant-Binding Protein family.

The addition of these 10 genomes to the roster of completed genomes is a further milestone in comparative genomics. As demonstrated by these companion studies, these sequences, along with the already well-annotated genome of Drosophila melanogaster, are an extremely useful tool in exploring speciation, evolution and development, and should be indispensable for biologists.


 

Patient Safety in Surgery - a new journal from BioMed Central

We are pleased to announce the launch of Patient Safety in Surgery, a new open access, independent journal, which covers all aspects of safety and quality of patient care in surgery and surgical subspecialties.

Morbidity and mortality in patients undergoing surgical procedures may largely be preventable. The key to improving the management of adverse events in surgery is understanding their causes. Patient Safety in Surgery aims to provide a scientific platform for specialists from all surgical fields, and other healthcare professionals to report, discuss, debate, and critically review all aspects related to errors, complications, and other safety issues in the management of patients undergoing surgical procedures.

Professor Philip Stahel (Denver Health Medical Center, University of Colorado School of Medicine) and Professor Pierre-Alain Clavien (University Hospital Zurich) Editors-in-Chief of Patient Safety in Surgery, are supported by an international Editorial Board.

Please read the launch editorial for further information about the journal.


 

Tuesday Nov 06, 2007

Six more BioMed Central journals accepted for inclusion in MEDLINE

We are pleased to announce that the following six BioMed Central titles have recently been accepted for inclusion in MEDLINE:

The journals were accepted for inclusion following review by the Literature Selection Technical Review Committee, an NIH-chartered advisory committee of external experts. The inclusion of these titles is a strong indicator of their growing stature in their respective fields, and the quality of the articles they have published to date.

In addition,  a number of BioMed Central journals have recently been accepted for inclusion in BIOSIS and Zoological Record. For more information, see BioMed Central's journal indexing information page.


 

Monday Nov 05, 2007

Proteome Science accepted for tracking by Thomson Scientific

We are delighted to announce that Proteome Science has been accepted for tracking by Thomson Scientific and is now on course to receive its first impact factor in 2009. The journal is one of 57 BioMed Central journals that are already tracked by Thomson Scientific and either have, or are on course to receive an impact factor.

Proteome Science was launched at the start of 2003 and has published articles on all aspects of proteomics, with a specific interest in the integration of functional of structural proteomic analysis with cell of developmental biology. This achievement is an important recognition of the growing reputation of this journal in its field.

Congratulations to the Editor-in-Chief, Martin Latterich!